Cisplatin vs carboplatin ototoxicity

Author: msqs

August undefined, 2024

WebChemotherapeutic (antineoplastic) drugs, particularly those containing platinum ( cisplatin and carboplatin ), can cause tinnitus and hearing loss. Hearing loss can be profound and permanent, occurring immediately after the first dose, or can be delayed until several months after completion of treatment. WebFinal results indicate that the investigational chemotherapeutic analogs CBDCA (JM-8) and CHIP (JM-9) do not produce the ototoxicity and nephrotoxicity characteristic of cisplatin. Furthermore, these findings demonstrate 195mpt localization in the vestibular labyrinth and confirm previous platinum distribution studies in the organ of Corti and ...

Ototoxicity of cisplatin vs. platinum analogs CBDCA (JM …

WebDec 7, 2024 · Background Extensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is indicated as the mainstay of treatment. In this study, we compared the efficacy and safety between the cisplatin plus etoposide (EP) and carboplatin plus etoposide (EC) regimens. Methods … WebA Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors: Actual Study Start Date ... [PROs] of ototoxicity) Note: participants in group 1 will not receive AGCT1531 protocol-directed therapy; all other AYA-HEARS patients must be ... importance of renal system

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebBesides myelosuppression, nephrotoxicity and ototoxicity are dose-limiting for cisplatin, whereas thrombocytopenia is dose-limiting for carboplatin. Cisplatin is extensively bound to plasma proteins and clear pharmacokinetic-PD correlations have been identified for the ultrafiltrable, i.e., unbound fraction of the drug in plasma and toxicity as ... WebCis-diamminedichloroplatinum (cisplatin), a divalent platinum compound and cell-cycle nonspecific chemotherapeutic agent, produces a permanent high-frequency … WebApr 26, 2024 · Tumors treated by cisplatin include adults with head and neck cancer and testicular, ovarian and lung cancers. Cisplatin is a key chemotherapeutic agent used to … literary devices used in harry potter

FDA approves sodium thiosulfate to reduce the risk of ototoxicity ...

The side effects of platinum-based chemotherapy drugs: …

WebMar 25, 2024 · The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity guidelines. Case series including retrospective medical records review of patients (age > 18) treated … literary devices used in laburnum topWebAug 19, 2007 · Pooling the results of all of these cis vs. carbo studies together, the response rate with cisplatin combinations was higher (30% vs. 24%), and the overall survival … importance of reporting abuse

"WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. … " - Cisplatin vs carboplatin ototoxicity

Cisplatin vs carboplatin ototoxicity

Mechanisms of Cisplatin-Induced Ototoxicity and …

WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This … WebMar 3, 2015 · Key clinical point: Paclitaxel plus carboplatin is noninferior to paclitaxel plus cisplatin for metastatic or recurrent cervical cancer. Major finding: The carboplatin regimen, with a median overall survival of 17.5 months, proved to be noninferior to the cisplatin regimen, which had a median OS of

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WebCarboplatin. Cisplatin. Loop diuretics (water pills) Loop diuretics help your kidneys move excess salt and fluid out of your body. Ototoxic types include: Bumetanide. Ethacrynic acid. Furosemide. Torsemide. Other ototoxic drugs and chemicals Rarer causes of ototoxicity include: Quinine: Drugs providers use to treat malaria. WebOct 8, 2010 · Carboplatin, a therapeutic alternative to cisplatin, has been shown to be less ototoxic, with reported toxicity rates of 0–38% [ 4, 10 – 12, 18, 19 ]. Carboplatin is also …

Web18/40 (45%) evidence of ototoxicity at audiometry. To date we have seen no neuro- or ototoxicity with carboplatin and 1/40 (2.5%) have developed WHO grade I renal toxicity. Myelo- ... Key words: Ovarian cancer; cisplatin, carboplatin, toxicity, efficacy, randomized study. Cisplatin is the most active drug in ovarian cancer ... WebHowever, we consider that elderly patients with age-related hearing impairment are more likely to suffer from ototoxicity of cisplatin and discontinue scheduled treatment. Therefore, elderly patients who require cisplatin treatment should be carefully managed. ... The EXTREME trial evaluated the effect of cetuximab on cisplatin/carboplatin plus ...

WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin crosses into the cochlea, which often results in permanent sensorineural cisplatin-induced hearing loss (CIHL). WebSep 15, 2024 · Carboplatin (kar" boe pla' tin) is a cisplatin analog with a carboxy-cyclobutane moiety instead of the chloride atoms which makes it more stable and perhaps less toxic than cisplatin. Carboplatin and cisplatin act as alkylating agents causing cross linking between and within DNA strands, leading to inhibition of DNA, RNA and protein …

WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 ... This is a review of cisplatin-induced ototoxicity and strategies to minimize the negative impact on QoL and outcome.

WebEfficacy and safety of a cisplatin and paclitaxel (TP) induction regimen followed by chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) importance of removing makeupWebThe platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. importance of renters insurance articlesWebFeb 1, 1991 · The main known side effects of cisplatin are a high emetogenic potential and various organotoxic effects. Cisplatin can be nephrotoxic (8), ototoxic (9) and neurotoxic (especially with peripheral ... importance of remote patient monitoringWebThe antineoplastic agent's cisplatin and carboplatin are widely used as they are highly effective. Unfortunately, ototoxicity is a frequently encountered side effect of platinum-based chemotherapy. Clinically, patients generally develop a progressive, bilateral, and irreversible sensorineural hearing loss. importance of renewable resourcesWebIbero-American Expert Consensus on Squamous Cell Carcinoma of the Head and Neck Treatment in Patients Unable to Receive Cisplatin Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. literary devices used in paradise lostWebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity. literary devices used in oliver twistWebMar 31, 2024 · Metal-based complexes contribute a vital part in the available arsenal of cytotoxic agents today. Platinum (II) complexes, specifically targeting genomic DNA (e.g., cisplatin and carboplatin), are widely used in the clinic for the treatment of various cancers. Nearly 50% of cancer patients, who undergo chemotherapy, receive a platinum … literary devices used in movies